一、个人简介

杨晶，女，1988年10月出生，博士、副研究员。

主要经历：

2018.8至今 73882必赢网页版，助理研究员

2017.7-2018.7东部战区总医院，助理研究员

2014.5-2016.4美国Virginia Commonwealth University，访问学者

2011.9-2017.6中国药科大学，博士

2007.9-2011.6安徽中医药大学，本科

二、研究领域

1.肝脏损伤与修复的机制研究及药物干预

2.重症胰腺炎、脓毒症等重症炎症性疾病的分子网络调控

3.天然活性物质筛选及分子机制

三、学术成果

（一）代表性项目

[1]国家自然科学基金青年基金项目，81900560，主持；

[2]江苏省自然科学基金青年项目，BK20180294，主持；

[3]中国博士后科学基金第67批面上资助，2020M671348，主持；

[4]无锡市科技发展医疗卫生指导性计划，主持；

[5]企业横向课题多项。

（二）代表性论文

[1]Jing Yang, Xujiao Tang, Zhu Liang,et al. Taurocholic Acid Promotes Hepatic Stellate Cell Activation via S1PR2/p38 MAPK/YAP Signaling under Cholestatic Conditions, Clinical and Molecular Hepatology.2023.

[2]Jing Yang, Xujiao Tang, Baiqiang Li,et al. Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic infammatory responses via NF-kappa B activation in acute pancreatitis. Cell Communication and Signaling, 2022, 20:157-168.

[3]Jing Yang, Xujiao Tang, Qingqing Wu,et al. Heparin Protects Severe Acute Pancreatitis by Inhibiting HMGB-1 Active Secretion from Macrophages. Polymers, 2022, 14: 2470-2483.

[4]Jing Yang, Xujiao Tang, Qingqing Wu,et al. A Severe Acute Pancreatitis Mouse Model Transited from Mild Symptoms Induced by A “Two-Hit” Strategy with L-Arginine. Life, 2022, 12, 126-137.

[5]Jing Yang, Xujiao Tang, Xue Ke,et al. Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis. International Journal of Molecular Sciences.2022, 23: 1252-1265.

[6]杨晶,刘晓妮,吴青青,等.6 -O-脱硫酸化肝素通过Syndecan-1 / c -Met / Akt途径延缓博来霉素诱导的肺损伤.中国药理学通报.2022,38(8):1147-1155.

[7]Jing Yang, Yiwen Zhou, Jinsong Shi. Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK. Life Sciences. 2020,251:117645.

[8]杨晶,倪佳良,高越颖.蛹虫草虫草素对ANIT诱导胆汁淤积性肝损伤的保护作用[J].菌物学报.2020,40 (2):1-9

[9] Yongqing Wang#, Hiroaki Aoki#,Jing Yang#,et al. The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice, Hepatology, 2017, 65(6): 2005-2018.

[10]Jing Yang, Lixin Sun, Lu Wang,et al. Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats, Frontiers in pharmacology, 2017, 8: 260.

[11]Jing Yang, Yunzhou Li, Phillip Hylemon,et al. Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation, Biomedicine & Pharmacotherapy, 2017, 95: 1777-1788.

（三）代表性专利

[1]肝素及其衍生物在预防和治疗肝衰竭中的应用.2023,中国,CN202310200058.X.

[2]一种抗纤维化的化合物.2023,中国,CN202310200267.4.

[3]一种肝素类似物在制备治疗或预防急性胰腺炎药物中的应用.2022,中国，CN202110527675.1.

四、联系方式

通讯地址：江苏省无锡市蠡湖大道1800号73882必赢网页版

邮编：214122

邮箱：yangjing@jiangnan.edu.cn

【以上资料更新日期】：2023年9月